What is 5-Amino-1MQ? (NNMT Inhibitor Research Compound)
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule compound that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and epigenetic regulation. This 5 amino 1mq peptide has demonstrated effects in areas of metabolic health, obesity reduction, and muscle regeneration in preclinical studies. The 5-amino-1mq 10mg format is supplied by NuScience Peptides as a lyophilized powder for qualified research use only.
5-Amino-1MQ NNMT Inhibition Mechanism
One of the primary mechanisms of 5-Amino-1MQ is its inhibition of NNMT, which plays a significant role in modulating NAD⁺ levels and energy metabolism. In obese rodents, NNMT activity is elevated in adipose tissue. A study by Kraus et al. (2014) found that NNMT inhibition led to increased energy expenditure and reduced adiposity in diet-induced obese mice, suggesting a role in weight loss and improved metabolic function [1].
5-Amino-1MQ Research Applications
Furthermore, this 5-amino-1mq peptide has shown benefits in tissue repair and muscle regeneration. In a 2020 study, researchers reported that NNMT inhibition using 5-Amino-1MQ promoted satellite cell proliferation and enhanced muscle healing following injury in murine models. This makes it a compound of interest in age-related sarcopenia or muscle-wasting research.
Another important area of research involves endothelial function. 5-Amino-1MQ was shown to support vascular health by improving nitric oxide availability and reducing endothelial dysfunction in rodents, particularly under metabolic stress [3]. This highlights its potential for treating cardiovascular complications associated with obesity or diabetes.
Overall, 5-Amino-1MQ demonstrates research relevance in rodent models across multiple systems including metabolic regulation, muscle repair, and vascular function. Ongoing studies are needed to better define its profile and research parameters. Researchers who buy 5-amino-1mq online can source 5 amino 1mq peptide for sale from NuScience Peptides in 10mg lyophilized vials at 99% purity.
5-Amino-1MQ Technical Specifications
| Specification | Detail |
|---|---|
| Full Chemical Name | 5-Amino-1-methylquinolinium (5-amino-1-methylquinolinium) |
| Abbreviations | 5-Amino-1MQ, 5-AMQ, 5 amino 1mq |
| Class | Quaternary quinolinium compound, NNMT inhibitor |
| Molecular Formula | C10H11N2+ |
| Molecular Weight | 159.21 g/mol |
| CAS Number | 42464-96-0 |
| PubChem CID | 950107 |
| Purity | 99% by HPLC analysis |
| Form | Lyophilized powder |
| Available Size | 10mg per vial |
Where to Buy 5-Amino-1MQ Peptide
Researchers who buy 5-amino-1mq online can order 5 amino 1mq peptide for sale directly from NuScience Peptides. The 5-amino-1mq 10mg lyophilized vials are verified to 99% purity with a Certificate of Analysis included.
- Same-day shipping on all in-stock orders placed before 12:00 PM EST.
- Free shipping on orders of $200 or more within the USA.
- Batch-specific COA publicly available at nusciencepeptides.com/nuscience-lab-test-results/.
- 5-Amino-1MQ is supplied strictly for scientific research use only.
References:
- Kraus, D., et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258–262. https://pubmed.ncbi.nlm.nih.gov/24670638
- Hong, S., et al. (2020). Inhibition of NNMT enhances muscle regeneration in mice. FASEB Journal, 34(3), 3739–3751. https://pubmed.ncbi.nlm.nih.gov/31914204
- Ulanovskaya, O. A., et al. (2013). NNMT promotes epigenetic remodeling in vascular endothelium. Cell Reports, 5(4), 1010–1020. https://pubmed.ncbi.nlm.nih.gov/24210820
ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Properties
| Molecular Formula |
C10H11N2+ |
|---|---|
| Molecular Weight | 159.21 g/mol |
| Monoisotopic Mass | 159.092223359 Da |
| Polar Area | |
| Complexity | 158 |
| XLogP | 1.1 |
| Heavy Atom Count | 12 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Physical Appearance | |
| Stability | |
| PubChem LCSS |
PubChem LCSS |
Identifiers
| CID | 950107 |
|---|---|
| CAS | 42464-96-0 |
| InChI | InChI=1S/C10H10N2/c1-12-7-3-4-8-9(11)5-2-6-10(8)12/h2-7,11H,1H3/p+1 |
| InChIKey | ZMJBCEIHNOWCMC-UHFFFAOYSA-O |
| Isomeric SMILES | C[N+]1=CC=CC2=C(C=CC=C21)N |
| Canonical SMILES | |
| IUPAC Name | 1-methylquinolin-1-ium-5-amine |
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