CJC-1295 NO-DAC (MOD GRF 1-29) – 5mg & 10mg

Name: CJC-1295 NO-DAC (MOD GRF 1-29) – 5mg &amp; 10mg
SKU: nu-1786008831350-50
Availability: InStock

Price range: $42.99 through $74.99

This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.

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SKU: nu-1786008831350-50 Category: Peptides Tags: Amino Club, CJC-1295 NO-DAC (MOD GRF 1-29) – 5mg & 10mg, Peptides, Research Compounds

Description
Additional information

CJC-1295 NO-DAC

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

CJC-1295 No DAC (also known as Mod GRF 1-29 or Modified GRF 1-29) is a synthetic analog of growth hormone-releasing hormone (GHRH) studied for its effects on GH and IGF-1 secretion in preclinical models. In rat models, this research peptide provides a tool for investigating endocrine regulation, growth axis signaling, and metabolic pathways. A study by Ionescu and Frohman (2006) demonstrated that CJC-1295 administration in rats led to increased GH secretion while preserving the natural pulsatile release pattern. This suggests that the peptide enhances GH levels without disrupting the physiological rhythm of hormone release, which is crucial for maintaining homeostasis.

Further research by Teichman et al. (2006) explored the pharmacokinetics and pharmacodynamics of CJC-1295 No DAC. Their findings indicated that a single subcutaneous injection in study subjects resulted in sustained elevations of GH and IGF-1 levels for several days, highlighting the Mod GRF 1-29 peptide’s extended activity profile in research models. In a study using growth hormone-releasing hormone knockout (GHRHKO) mice, Alba et al. (2006) found that daily administration of CJC-1295 No DAC normalized growth parameters and body composition in the research model. These findings contribute to the understanding of GHRH analog activity in preclinical growth deficit models.

The mechanism behind CJC-1295’s extended half-life involves its bioconjugation with serum albumin, as detailed by Lapierre et al. (2005). This modification allows the Mod GRF 1-29 peptide to remain in circulation longer in research models, supporting its extended activity profile compared to native GHRH. Collectively, these studies support CJC-1295 No DAC (Mod GRF 1-29) as a research tool in endocrinology for investigating GH dynamics and GHRH receptor interactions in preclinical models. NuScience Peptides supplies CJC-1295 No DAC in 5mg and 10mg lyophilized vials, lab tested, for laboratory research use only. Certificates of Analysis are available on the NuScience Lab Test Results page.

CJC-1295 No DAC vs CJC-1295 with DAC Comparison

Feature	CJC-1295 No DAC (Mod GRF 1-29)	CJC-1295 with DAC
Also known as	Mod GRF 1-29, Modified GRF 1-29	CJC-1295, DAC-GRF
Drug Affinity Complex (DAC)	No	Yes
Amino acids	29	30 (with DAC modification)
Approximate half-life in models	~30 minutes (shorter)	Several days (extended)
GH pulse pattern	Preserves natural pulsatile pattern	Sustained continuous elevation
Common research use	Pulsatile GH release studies	Extended GH elevation studies
Available at NuScience	Yes – 5mg and 10mg	Yes

Handling, Reconstitution and Storage

Store lyophilized CJC-1295 No DAC vials at -20C until use
Reconstitute with bacteriostatic water under aseptic conditions
Use the NuScience Peptide Calculator to determine the correct BAC water volume for your research concentration
Once reconstituted, store at 4C and use within the research protocol window
For comprehensive storage protocols, refer to the NuScience Peptide Handling and Storage guide
This product is for laboratory research use only. Not for human consumption.

References:

Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792–4797. https://pubmed.ncbi.nlm.nih.gov/17018654/
Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805. https://pubmed.ncbi.nlm.nih.gov/16352683/
Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290–E1294. https://pubmed.ncbi.nlm.nih.gov/16822960/
Lapierre, H., Bonin, A., & Dubuc, J. (2005). Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology, 146(7), 3052–3058. https://pubmed.ncbi.nlm.nih.gov/15817669/

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Properties

Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	3367.9
Monoisotopic Mass	3365.8935782
Polar Area	1450
Complexity	7710
XLogP	-10.7
Heavy Atom Count	238
Hydrogen Bond Donor Count	52
Hydrogen Bond Acceptor Count	48
Rotatable Bond Count	118
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	CJC-1295 NO-DAC (MOD GRF 1-29) Laboratory Chemical Safety Summary

Identifiers

CID	56841945
CAS	446262-90-4
InChI	InChI=1S/C152H252N44O42/c1-22-79(15)118(194-125(214)84(20)171-135(224)107(68-115(206)207)181-124(213)81(17)169-126(215)91(155)65-87-41-45-89(201)46-42-87)147(236)189-106(66-86-34-25-24-26-35-86)141(230)196-120(85(21)200)149(238)180-99(51-54-114(158)205)132(221)190-111(72-199)145(234)185-105(67-88-43-47-90(202)48-44-88)140(229)178-96(40-33-59-168-152(164)165)128(217)177-94(37-28-30-56-154)133(222)193-117(78(13)14)146(235)187-100(60-73(3)4)134(223)170-82(18)123(212)175-97(49-52-112(156)203)130(219)183-103(63-76(9)10)138(227)191-109(70-197)143(232)172-83(19)122(211)174-95(39-32-58-167-151(162)163)127(216)176-93(36-27-29-55-153)129(218)182-102(62-75(7)8)137(226)184-101(61-74(5)6)136(225)179-98(50-53-113(157)204)131(220)186-108(69-116(208)209)142(231)195-119(80(16)23-2)148(237)188-104(64-77(11)12)139(228)192-110(71-198)144(233)173-92(121(159)210)38-31-57-166-150(160)161/h24-26, 34-35, 41-48, 73-85, 91-111, 117-120, 197-202H, 22-23, 27-33, 36-40, 49-72, 153-155H2, 1-21H3, (H2, 156, 203)(H2, 157, 204)(H2, 158, 205)(H2, 159, 210)(H, 169, 215)(H, 170, 223)(H, 171, 224)(H, 172, 232)(H, 173, 233)(H, 174, 211)(H, 175, 212)(H, 176, 216)(H, 177, 217)(H, 178, 229)(H, 179, 225)(H, 180, 238)(H, 181, 213)(H, 182, 218)(H, 183, 219)(H, 184, 226)(H, 185, 234)(H, 186, 220)(H, 187, 235)(H, 188, 237)(H, 189, 236)(H, 190, 221)(H, 191, 227)(H, 192, 228)(H, 193, 222)(H, 194, 214)(H, 195, 231)(H, 196, 230)(H, 206, 207)(H, 208, 209)(H4, 160, 161, 166)(H4, 162, 163, 167)(H4, 164, 165, 168)/t79-, 80-, 81+, 82-, 83-, 84-, 85+, 91-, 92-, 93-, 94-, 95-, 96-, 97-, 98-, 99-, 100-, 101-, 102-, 103-, 104-, 105-, 106-, 107-, 108-, 109-, 110-, 111-, 117-, 118-, 119-, 120-/m0/s1
InChIKey	XOZMWINMZMMOBR-HRDSVTNWSA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N
IUPAC Name	(3S)-4-[[(2S)-1-[[(2S, 3S)-1-[[(2S)-1-[[(2S, 3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S, 3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid

mg	10mg, 5mg
Storage	Room Temperature (15-30°C)