Melanotan II
This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
Melanotan II 10 mg (MT-II)/Melanotan 2 is a synthetic analog of α-melanocyte-stimulating hormone and a potent non-selective agonist of melanocortin receptors (MCRs). This melanotan II peptide is widely used in preclinical research to study energy homeostasis, feeding behavior, thermoregulation, and neuroendocrine functions in rodent models.
One of the primary applications of melanotan II peptide in rodent research is its anorexigenic effect. Central administration of MT-II significantly reduces food intake and body weight in rats, implicating melanocortin-3 and -4 receptors (MC3R and MC4R) in the regulation of appetite and energy balance. These effects are observed when MT-II is administered into various brain regions, including the forebrain and hindbrain ventricles, suggesting a distributed control of feeding behavior via MCRs.
In addition, Melanotan II 10 mg has been shown to influence thermoregulation. Peripheral administration induces hypothermia in mice by activating mast cells and stimulating histamine receptors, highlighting a mechanism independent of canonical melanocortin receptors. This demonstrates the complex interplay between melanotan 2 peptide and various physiological systems beyond the central nervous system.
Moreover, MT-II has demonstrated potential in enhancing recovery following neural injury. In a rat model of sciatic nerve crush injury, administration of melanotan II peptide significantly improved sensory function recovery, suggesting a role in promoting neural regeneration.
Melanotan II 10 mg also affects sexual behavior in rodents. Studies show MT-II enhances proceptive sexual behaviors in female rats, indicating its influence on sexual motivation and behavior through central melanocortin pathways.
Additionally, MT-II has been implicated in modulating reward-related behaviors. Microinjection of melanotan 2 peptide into the nucleus accumbens of rats reduced motivation to obtain food without affecting actual intake, supporting its use as a research tool in appetite and behavior studies.
In summary, Melanotan II 10 mg serves as a valuable tool for investigating melanocortin system pathways in rodent research. Its multifaceted effects on feeding, thermoregulation, neural recovery, sexual behavior, and motivation underscore the importance of this melanotan II peptide in preclinical studies.
References:
- Raposinho, P. D., White, R. B., & Aubert, M. L. (2003). The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology, 15(2), 173–181.
- Jain, S., Panyutin, A., Liu, N., Xiao, C., Pinol, R. A., & Pundir, P. (2018). Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E357–E366.
- The potent melanocortin receptor agonist melanotan-II promotes recovery of sensory function following sciatic nerve injury in rats. European Journal of Pharmacology, 2002.
- The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacology Biochemistry and Behavior, 2006.
- Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens reduces motivation to obtain food in rats. Physiology & Behavior, 2022.
ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Properties
| Molecular Formula |
C50H69N15O9 |
|---|---|
| Molecular Weight | 1024.2 |
| Monoisotopic Mass | 1023.54026884 |
| Polar Area | 385 |
| Complexity | 1950 |
| XLogP | 0 |
| Heavy Atom Count | 74 |
| Hydrogen Bond Donor Count | 13 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 17 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Melanotan II Laboratory Chemical Safety Summary |
Identifiers
| CID | 92432 |
|---|---|
| CAS | 121062-08-6 |
| InChI | InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9, 13-15, 17, 26-28, 35-41, 57H, 3-4, 10-12, 16, 18-25H2, 1-2H3, (H2, 51, 68)(H, 54, 58)(H, 55, 67)(H, 59, 66)(H, 60, 72)(H, 61, 71)(H, 62, 73)(H, 63, 70)(H, 64, 74)(H, 65, 69)(H4, 52, 53, 56)/t35-, 36-, 37-, 38+, 39-, 40-, 41-/m0/s1 |
| InChIKey | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| Isomeric SMILES | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C |
| Canonical SMILES | CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C |
| IUPAC Name | (3S, 6S, 9R, 12S, 15S, 23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2, 5, 8, 11, 14, 17-hexaoxo-1, 4, 7, 10, 13, 18-hexazacyclotricosane-23-carboxamide |
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