Snap-8
This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
SNAP-8, also known as acetyl octapeptide-3, is a synthetic snap 8 peptide developed as a topical alternative to botulinum toxin (BoNT) for reducing dynamic facial wrinkles. It functions by inhibiting the SNARE complex, thereby modulating neurotransmitter release and attenuating muscle contractions that lead to expression lines. (ResearchGate)
In vitro studies have demonstrated that the snap 8 peptide can decrease the depth of wrinkles by up to 63% by reducing muscle contractions. This effect is attributed to its ability to inhibit the formation of the SNARE complex, which is essential for neurotransmitter release at the neuromuscular junction. By preventing this complex’s assembly, SNAP-8 reduces muscle activity, leading to a smoother skin appearance. (HubMedEd)
Clinical evaluations have further supported SNAP-8’s efficacy. A study assessing a serum containing SNAP-8 reported a significant reduction in wrinkle depth after four weeks of application, with participants exhibiting improved skin smoothness and elasticity. These findings are often referenced by individuals looking to buy snap-8 peptide for advanced cosmetic research, as the data highlights its performance potential. (PMC)
Analytical methods have been developed to quantify SNAP-8 in cosmetic formulations, ensuring product consistency and efficacy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques have been employed to detect and measure SNAP-8 concentrations in various delivery systems, including microneedle patches. These methods provide accurate quantification, facilitating quality control in product development. (SpringerOpen)
The increasing popularity of SNAP-8 in the cosmetic industry is reflected in consumer interest and market trends. A longitudinal analysis of internet search data indicated a growing public interest in acetyl hexapeptide-8, the trade name for SNAP-8, over the past decade—particularly among users wanting to know where to buy SNAP-8 peptide as non-invasive, cost-effective alternatives to BoNT continue to scale. (PMC)
In summary, SNAP-8 is a promising peptide for cosmetic applications, offering a non-invasive approach to reducing facial wrinkles. Its mechanism of action, clinical efficacy, and growing consumer interest underscore its potential as a valuable ingredient in anti-aging skincare products.(ResearchGate)
Works Cited
- Jung, Jae Hoon, et al. “Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry.” Journal of Analytical Science and Technology, vol. 11, no. 1, 2020, pp. 1-9. https://jast-journal.springeropen.com/articles/10.1186/s40543-020-00232-8(SpringerOpen)
- “Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.” PubMed Central, National Institutes of Health, https://pmc.ncbi.nlm.nih.gov/articles/PMC10915729/(PMC)
- “Investigating the effects of Argireline in a skin serum containing acetyl hexapeptide-8.” PubMed Central, National Institutes of Health, https://pmc.ncbi.nlm.nih.gov/articles/PMC10665711/(PMC)
- “Non-Invasive Peptides as the Future of Botox Alternatives.” MDPI, https://www.mdpi.com/2079-9284/11/4/118(MDPI)
ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Properties
| Molecular Formula |
|
|---|---|
| Molecular Weight | 1075.2 g/mol |
| Monoisotopic Mass | 1074.48764138 Da |
| Polar Area | 585 Ų |
| Complexity | 2070 |
| XLogP | -7.7 |
| Heavy Atom Count | 74 |
| Hydrogen Bond Donor Count | 17 |
| Hydrogen Bond Acceptor Count | 19 |
| Rotatable Bond Count | 38 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | |
| PubChem LCSS |
Identifiers
| CID | 86080331 |
|---|---|
| CAS | |
| InChI | InChI=1S/C41H70N16O16S/c1-19(33(67)57-27(32(43)66)18-31(64)65)50-34(68)21(6-4-15-48-40(44)45)52-35(69)22(7-5-16-49-41(46)47)53-37(71)24(8-11-28(42)59)54-39(73)26(14-17-74-3)56-38(72)25(10-13-30(62)63)55-36(70)23(51-20(2)58)9-12-29(60)61/h19,21-27H,4-18H2,1-3H3,(H2,42,59)(H2,43,66)(H,50,68)(H,51,58)(H,52,69)(H,53,71)(H,54,73)(H,55,70)(H,56,72)(H,57,67)(H,60,61)(H,62,63)(H,64,65)(H4,44,45,48)(H4,46,47,49) |
| InChIKey | KMACPCJUCHVVGP-UHFFFAOYSA-N |
| Isomeric SMILES | CC(C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C |
| Canonical SMILES | |
| IUPAC Name | 4-acetamido-5-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[(1-amino-3-carboxy-1-oxopropan-2-yl)amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
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