NAD+

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

What is NAD+ Peptide?

NAD+ peptide, also known as nicotinamide adenine dinucleotide, is a vital coenzyme involved in cellular metabolism, DNA repair, and mitochondrial function. Researchers looking to buy NAD+ for laboratory studies will find this lyophilized NAD+ compound has been extensively studied in rat models, revealing its potential in mitigating various pathological conditions.

NAD+ Research in Animal Models

In rat models, NAD⁺ supplementation has been extensively studied, revealing its potential in mitigating various pathological conditions.

NAD+ Neuroprotective Effects

One significant area of research focuses on NAD⁺’s neuroprotective effects. In a study examining chronic cerebral hypoperfusion in rats, NAD⁺ administration improved cognitive function and reduced neuroinflammation by enhancing mitochondrial function and decreasing reactive oxygen species production. This suggests NAD⁺’s potential in treating neurodegenerative diseases.

NAD+ and Exercise Endurance Research

NAD⁺ has been implicated in enhancing exercise endurance. A study demonstrated that treatment with NAD⁺ and honokiol improved exercise capacity in rats by restoring SIRT3 levels in skeletal muscles and enhancing mitochondrial complex I levels.

NAD+ Safety Research

Safety assessments of NAD⁺ precursors like nicotinamide riboside (NR) have also been conducted. A 90-day oral toxicity study in Sprague-Dawley rats found no adverse effects at doses up to 1,200 mg/kg/day, supporting the safe use of NR in long-term studies.Additionally, NAD⁺ supplementation has been shown to protect against spinal cord ischemia-reperfusion injury in rats by reducing oxidative stress-induced neuronal apoptosis, highlighting its potential in treating spinal cord injuries.These findings underscore the therapeutic potential of NAD⁺ in various disease models. However, further research is necessary to fully elucidate its mechanisms and translate these benefits into clinical applications.

References

Pei, Zuowei, et al. “The Role of NAD⁺ in Myocardial Ischemia-induced Heart Failure in Sprague-Dawley Rats and Beagles.” Current Pharmaceutical Biotechnology, vol. 25, no. 17, 2024, pp. 2300–2311. PubMed
Ferdaus, Sara Amelia, et al. “NAD⁺ Deficiency Plays Essential Roles in the Hyperuricemia of Stroke-Prone Spontaneously Hypertensive Rat via Xanthine Dehydrogenase to Xanthine Oxidase Conversion.” Biochemical and Biophysical Research Communications, vol. 744, 2025, p. 151136. PubMed
Zhang, Ning, et al. “NAD⁺ Improves Cognitive Function and Reduces Neuroinflammation in Rats with Chronic Cerebral Hypoperfusion.” Neuroscience Letters, vol. 748, 2021, p. 135700. PubMed
Conze, Douglas, et al. “Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (Nicotinamide Riboside Chloride) in Sprague-Dawley Rats.” Toxicology Reports, vol. 7, 2020, pp. 1–10. PubMed
Gökce, E. C., et al. “Protective Effect of Nicotinamide Adenine Dinucleotide Against Spinal Cord Ischemia-Reperfusion Injury in Rats.” Journal of Neurosurgery: Spine, vol. 24, no. 6, 2016, pp. 949–959. PubMed

NuScience Peptides sells research products only, they are not for human consumption.

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Properties

Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.4
Monoisotopic Mass	663.10912256
Polar Area	321
Complexity	1120
XLogP	-6
Heavy Atom Count	44
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	11
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	Laboratory Chemical Safety Summary (LCSS) Datasheet

Identifiers

CID	5892
CAS	53-84-9
InChI	InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKey	BAWFJGJZGIEFAR-NNYOXOHSSA-N
Isomeric SMILES	C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Canonical SMILES	C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
IUPAC Name	[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

NAD+ Peptide – 500mg