MOTS-c Research Peptide for Sale

MOTS-C Research Peptide

MOTS-c research peptide for sale at 99%+ purity, confirmed by HPLC and mass spectrometry and supplied with a batch-specific Certificate of Analysis for every lot. NuScience Peptides ships same day from the USA for in vitro and analytical research use only.

What Is MOTS-c?

MOTS-c is a mitochondrial-derived peptide, a 16-amino-acid sequence encoded within the mitochondrial 12S rRNA region rather than the nuclear genome. In research it is studied for its role in metabolic regulation and AMPK-pathway signaling, and it is of interest as one of the few known peptides originating from mitochondrial DNA. This distinguishes it from the receptor-agonist and copper peptides elsewhere in the catalog.

MOTS-c Purity and COA Verification

Every batch is independently third-party tested in the USA and verified by HPLC and mass spectrometry to confirm identity and 99%+ purity, with a batch-specific Certificate of Analysis published for each lot. To compare specifications across the catalog, browse all research peptides.

Buy MOTS-c Research Peptide Online

NuScience Peptides supplies MOTS-c in 20mg and 40mg research-grade vials. Orders placed before 12 PM EST ship the same day from the USA, with free shipping over $200. Browse the wider catalog of research peptides for sale and review the Certificate of Analysis for any batch before ordering.

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

MOTS-C is a mitochondrial-derived research peptide that has gained increasing attention within experimental and preclinical research for its involvement in metabolic regulation, cellular stress response, and energy signaling pathways. As a bioactive mitochondrial peptide, the MOTS-C peptide is actively studied for its role in maintaining cellular homeostasis across multiple physiological systems.

Preclinical rat studies indicate that MOTS-C expression is closely linked to metabolic adaptation. In diabetic sand rat models, an eight-week protocol of moderate-intensity interval training resulted in elevated endogenous MOTS-C levels. This increase was associated with improved insulin sensitivity and upregulation of key metabolic regulators, including PGC-1α, GLUT4, and AMPK, suggesting a role in mitochondrial biogenesis and glucose metabolism. These findings position MOTS-C peptides for sale strictly within metabolic research frameworks.

Beyond metabolic research, MOTS-C has demonstrated cardioprotective potential in controlled laboratory models. In myocardial ischemia-reperfusion injury studies, MOTS-C administration reduced ferroptosis by activating the PPARγ signaling pathway, leading to attenuation of secondary acute lung injury. This highlights its relevance in cardiovascular and pulmonary cellular stress models.

Neurological research further supports the significance of MOTS-C. In rotenone-induced neurotoxicity models, MOTS-C pretreatment activated the Nrf2/HO-1/NQO1 antioxidant pathway, limiting oxidative stress and preserving dopaminergic neuron integrity. These outcomes reinforce the peptide’s value in neurodegenerative disease research environments.

Additionally, MOTS-C has shown promising results in skeletal biology research. In osteoporotic rat models, MOTS-C facilitated osteogenic differentiation of bone marrow mesenchymal stem cells through TGF-β/Smad signaling, contributing to enhanced bone formation and structural integrity.

Collectively, these findings underscore the versatility of MOTS-C 20 mg research peptide across metabolic, cardiovascular, neurological, and skeletal research domains. While these results are derived exclusively from controlled laboratory studies, they continue to drive scientific interest and ongoing investigation.

References

1. Parseh, Sahar, et al. “An 8-Week Study on the Effects of High and Moderate-Intensity Interval Exercises on Mitochondrial MOTS-C Changes and Their Relation to Metabolic Markers in Male Diabetic Sand Rats.” Diabetes Research and Clinical Practice, vol. 212, 2024, p. 111656. https://pubmed.ncbi.nlm.nih.gov/38636847/
2. Li, Y., et al. “The Mitochondrial-Derived Peptide MOTS-c Suppresses Ferroptosis and Alleviates Acute Lung Injury Induced by Myocardial Ischemia Reperfusion.” Biochemical and Biophysical Research Communications, vol. 636, 2023, pp. 1–9. https://pubmed.ncbi.nlm.nih.gov/37290680/
3. Wang, X., et al. “The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Regulate Antioxidant Defense System in PC12 Cells and Rats.” Free Radical Biology and Medicine, vol. 193, 2023, pp. 1–10. https://pubmed.ncbi.nlm.nih.gov/37380822/
4. Hu, B.-T., et al. “MOTS-c Improves Osteoporosis by Promoting Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via TGF-β/Smad Pathway.” European Review for Medical and Pharmacological Sciences, vol. 22, no. 21, 2018, pp. 7156–7163. https://pubmed.ncbi.nlm.nih.gov/30468456/
5. Zhang, L., et al. “MOTS-c Regulates the ROS/TXNIP/NLRP3 Pathway to Alleviate Myocardial Injury in Diabetic Rats.” Journal of Molecular and Cellular Cardiology, vol. 181, 2024, pp. 1–10. https://pubmed.ncbi.nlm.nih.gov/39616938/

NuScience Peptides sells research products only, they are not for human consumption.

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Properties

Molecular Formula	C101H152N28O22S2
Molecular Weight	2174.6 g/mol
Monoisotopic Mass	2173.1077409 g/mol
Polar Area	890A2
Complexity	4510
XLogP
Heavy Atom Count
Hydrogen Bond Donor Count	31
Hydrogen Bond Acceptor Count	29
Rotatable Bond Count	73
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	PubChem MOTS-c

Identifiers

CID	146675088
CAS	1627580-64-6
InChI	InChI=1S/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/m0/s1
InChIKey	WYTHCOXVWRKRAH-LOKRTKBUSA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)CNC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)N
IUPAC Name	(4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid